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Giovani ed Europa a Turate: Ciclo di incontri dedicato alle opportunità di mobilità per i giovani in Europa

Giovani ed Europa a Turate: venerdi 21 gennaio si terrà il secondo appuntamento del ciclo di incontri dedicato alle opportunità di mobilità per i giovani in Europa

Labopharm Europe Limited: Labopharm Europe Opens New Headquarters in Dublin, Ireland

Company Nearing Commercialisation of Once-Daily Formulation of Tramadol in Europe /PR Newswire/DUBLIN, Ireland

INTERNATIONAL MIGRATION IN EUROPE: NEW TRENDS, NEW METHODS OF ANALYSIS

2nd Conference of the EAPS Working Group on International Migration in Europe

Europe on alert for anniversary

LONDON, England -- Europe is on high alert as the continent commemorates the first anniversary of the September 11 terrorist attacks.

SelectUSA Program - New Record of $200 Billion in Foreign Direct Investments

Direct evidence for grain boundary passivation in Cu(In,Ga)Se2 solar cells through alkali-fluoride post-deposition treatments

Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast

• Otx2 binds to the promoter/enhancer region of Oct4, Sox2, and Nanog in ESCs and EpiSCs • Otx2 binding to the Nanog promoter helps maintain the integrity of ESC compartments • Loss of this Otx2-binding site induces primed-like features in ESCs • Otx2 regulation of Nanog contributes to ICM differentiation of the epiblast Mouse embryonic stem cells (ESCs) and the inner cell mass (ICM)-derived epiblast exhibit naive pluripotency. ESC-derived epiblast stem cells (EpiSCs) and the postimplantation epiblast exhibit primed pluripotency. Although core pluripotency factors are well-characterized, additional regulators, including Otx2, recently have been shown to function during the transition from naive to primed pluripotency. Here we uncover a role for Otx2 in the control of the naive pluripotent state. We analyzed Otx2-binding activity in ESCs and EpiSCs and identified Nanog, Oct4, and Sox2 as direct targets. To unravel the Otx2 transcriptional network, we targeted the strongest Otx2-binding site in the Nanog promoter, finding that this site modulates the size of specific ESC-subtype compartments in cultured cells and promotes Nanog expression in vivo, predisposing ICM differentiation to epiblast. Otx2-mediated Nanog regulation thus contributes to the integrity of the ESC state and cell lineage specification in preimplantation development.

Le Pubbliche Relazioni web 2.0 ! & Direct E-Mail MArketing!

Connecting Managers propone una giornata formativa in due sessioni.

Cubase SX3 takes music production to a new level

Europe's Digital Decade: Commission sets the course towards a digitally empowered Europe by 2030

Il 19 ottobre “Tradurre il cibo: il valore aggiunto della traduzione per l’economia e la società”

Translating Europe Workshop organizzato dalla Commissione europea e dall’Università di Parma in modalità online

5 dicembre: gli studenti Erasmus dell’Università di Parma raccontano l’Europa

Convegno “Europe in a blink - lo sguardo dei giovani sull’Europa. Diritti, doveri e opportunità”